Objective:The objective of the present study was to determine if the administration of sildenafil (Viagra) in a clinical setting in men with erectile dysfunction (ED) is associated with a risk of adverse events such as priapism, hypotension, and pulmonary embolism.
Methods:This prospective study was conducted on a group of 40 ED patients with mild-to-moderate ED (defined as male to female ratio ≥ 2.0) who were treated with Viagra (25 mg), sildenafil (25 mg) or placebo. Patients were followed up during 6 months and included in the study.
Results:During the study, 40 patients had a baseline event and 4 had a change from baseline. The patients were followed up with the follow up of 4 to 6 months, and they were able to complete a full medical history and follow up.
Conclusion:This study suggests that men with ED who take Viagra (Viagra) are at a higher risk for adverse events such as hypotension and priapism, which are potentially life-threatening in the context of ED. The combination of sildenafil and Viagra is associated with a low risk of adverse events in men with ED.
Viagra 50mgKeywords:Viagra, sildenafil, erectile dysfunction, priapism, hypotension, pulmonary embolism, hypotension, priapism, hypotension, pulmonary embolism, hypotension, pulmonary embolism
IntroductionViagra is a phosphodiesterase type-5 inhibitor (PDE-5i). The recommended dose of Viagra is 50 mg. This drug has been widely used in the treatment of erectile dysfunction (ED). The effects of Viagra have been studied in numerous studies and some of them have shown an increase in blood pressure. In a group of men with ED, 50 mg sildenafil is the recommended dose. This study aimed to assess the clinical efficacy and safety of the administration of 50 mg sildenafil in patients with ED treated with Viagra, sildenafil or placebo in the treatment of ED.
The protocol was approved by the institutional review boards of the University of Basel, Basel and the University of Basel Ethics Committee, and the patients provided written informed consent for the study.
In a group of 40 patients who had been treated with Viagra (Viagra) for ED, the mean change in systolic blood pressure (SBP) was 3.8 mm Hg (1.6 mOsm/cm2) in the group that received Viagra (Viagra) and 4.1 mm Hg (1.6 mOsm/cm2) in the group that did not take Viagra. In the placebo group, the mean change in systolic blood pressure (SBP) was 4.7 mm Hg (1.3 mOsm/cm2) in the group that received placebo and 3.6 mm Hg (1.3 mOsm/cm2) in the group that did not take placebo. In the Viagra group, the mean change in systolic blood pressure (SBP) was 3.6 mm Hg (1.4 mOsm/cm2) in the group that received Viagra and 3.1 mm Hg (1.4 mOsm/cm2) in the group that did not take Viagra. In the sildenafil group, the mean change in systolic blood pressure (SBP) was 3.7 mm Hg (1.2 mOsm/cm2) in the group that received Viagra and 3.7 mm Hg (1.2 mOsm/cm2) in the group that did not take Viagra.
In a group of 40 patients who had been treated with Viagra (Viagra) for ED, the mean change in systolic blood pressure (SBP) was 4.6 mm Hg (1.3 mOsm/cm2) in the group that received Viagra and 2.9 mm Hg (1.2 mOsm/cm2) in the group that did not take Viagra. In the placebo group, the mean change in systolic blood pressure (SBP) was 4.5 mm Hg (1.5 mOsm/cm2) in the group that received placebo and 4.2 mm Hg (1.5 mOsm/cm2) in the group that did not take placebo.
Chloramphenicol
The use of this drug is contraindicated because the use of chloramphenicol will increase the effect of Sildenafil by affecting the patient hepatic and intestinal enzyme metabolism.
Isosorbide dinitrate
The use of this drug is contraindicated because the combination of this drug either increases the effects of the other by vasodilation which leads to fatal hypotension.
Nitroprusside sodium
The use of this drug is contraindicated because the combination of this drug either increases the effects of the others by pharmacodynamic synergism.
Enzalutamide
Use alternative drugs because the use of enzalutamide will decrease the effect of Sildenafil by affecting patient hepatic and intestinal enzyme metabolism.
Acetazolamide
Therapy should be administered with caution because the use of Sildenafil increases the effect of acetazolamide by pharmacodynamic synergism and it also increases the risk of hypotension.
The use of this medicine can lower blood pressure and when combining it with alcohol further increases the effect. You may experience dizziness, lightheadedness, fainting, flushing, headache, and heart palpitation. Also, avoid consuming grapefruit juice because it may increase the effect of avanafil on blood levels.
Cardiovascular disease:
The use of phosphodiesterase-5 enzyme inhibitors is contraindicated in patients with cardiovascular disease. A doctor should consider the vasodilatory effects of this drug and whether they may affect patients with cardiovascular disease. The use of this drug may increase the risk of angina pectoris, AV block, myocardial infarction, ventricular arrhythmia, tachycardia, palpitation, hypotension, postural hypotension, syncope, cerebral thrombosis, cerebrovascular hemorrhage, transient ischemic attack, cardiac arrest, heart failure, and hypertension. These events can occur during or after sexual activity.
Renal dysfunction:
Therapy should be administered with caution in patients with severe renal disease or on renal dialysis. The plasma clearance of this drug is decreased in patients with a severe renal impairment which results in drug accumulation.
Liver diseases:
The use of this drug is not recommended for patients with severe hepatic impairment because the pharmacokinetic disposition of this drug has not been assessed in patients with severe hepatic impairment.
Addictive (IDs and their their their their with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with with.Views (23) of Type 2 diabetes: This medicine is not recommended for use in patients with a history of diabetes. This medicine is not recommended for use in patients with a history of diabetes. There is no information on the safety of using this medicine with patients with a history of heart problems.As with any drug product, there may be side effects. Generally, patients who experience side effects usually get them within 12 to 24 hours after taking sildenafil. Side effects can include:
Some other side effects you might experience:
It is also possible to experience side effects from taking sildenafil such as:
Some people may experience side effects from taking sildenafil such as:
For more information, please read the. You can follow the on-line instructions on your medicine cabinet or ask your pharmacist for specific instructions if you are not sure about any. Patient information leaflet is a useful resource.
Mechanism of action| Indication | Mechanism of Action |
|---|---|
| Sildenafil (Viagra) | Treats erectile dysfunction |
| Viagra (Sildenafil) | Enhances blood flow to penis |
| Viagra Connect (sildenafil) | |
| Viagra Together (sildenafil, Viagra Connect) |
Patients should be told to wait at least 2 hours after taking sildenafil before having sex. If the erection lasts longer than 4 hours, the patient should stop taking sildenafil and contact a doctor. Some common side effects of sildenafil include:
Some medications can affect how sildenafil works, and some of the medications that may interact with sildenafil are listed below:
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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Your safe and easy experience with Sildenafil is crucial for millions of men with erectile dysfunction.
SILDENAFIL 100MG TABis a generic medication for treating erectile dysfunction (ED) in men. Sildenafil citrate, the active ingredient in Viagra, works by increasing blood flow to the penis, helping men achieve and maintain an erection during sexual activity.
Key Benefits:
How to Use:
Storage:
Store below 30°C.
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